Release of 5-Aminosalicylic Acid (5-ASA) from Mesalamine Formulations at Various pH Levels
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منابع مشابه
Release of 5-Aminosalicylic Acid (5-ASA) from Mesalamine Formulations at Various pH Levels
INTRODUCTION Oral formulations of 5-aminosalicylic acid (5-ASA) for treatment of ulcerative colitis have been developed to minimize absorption prior to the drug reaching the colon. In this study, we investigate the release of 5-ASA from available oral mesalamine formulations in physiologically relevant pH conditions. METHODS Release of 5-ASA from 6 mesalamine formulations (APRISO®, Salix Phar...
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INTRODUCTION Mesalamine (5-aminosalicylic acid; 5-ASA) is recommended first-line therapy for mild-to-moderate ulcerative colitis. Many mesalamine formulations employ a pH-dependent release mechanism designed to maximize drug release in the colon. This study compared the in vitro release of 5-ASA from six commercially available mesalamine formulations at pH levels similar to those typically enco...
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Segmented polyurethanes containing azo aromatic groups in the main chain were synthesized by reaction of 3,3'-azobis(6-hydroxybenzoic acid) (ABHB), 5-[4-(hydroxyphenyl)azo] salicylic acid (HPAS), and 5-[1-hydroxynaphthyl)azo] salicylic acid (HNAS) with hexamethylenediisocyanate (HDI). All synthesized monomers and polymers were characterized by elemental analysis, FTIR, 1H-NMR spectra, TGA and D...
متن کاملIn-vitro dissolution testing of 5-aminosalicylic acid release from pH dependent mesalazine formulations.
Figure 2 Experiment B: dissolution of Salofalk 1.5 g granules (batch no. 10F18833L) and Mezavant 1200 mg (batch no VB032) at sequential pH 1.0, 6.0, and 6.8 (n=6). We have read with interest the abstract presented at the last ECCO Congress by Tenjarla & Abinusawa1. While we agree with the authors' final statement that ‘consideration of the potential release profiles [of 5-ASA] may be a useful t...
متن کاملElectrochemical Synthesis of 5-Aminosalicylic Acid from 5- Nitrosalicylic Acid in Alkaline Media
5-Aminosalicylic acid (5-ASA) is currently prepared by electrochemical reduction of 5-nitrosalicylic acid (5-NSA) in acidic media. In this work, electrolytic reduction of 5-NSA in alkaline media is presented. Reactionconditions and parameters such as anode and cathode electrodes, electrolyte type, reaction time, temperature,current, and the pH for isolation of product are investigated. The yiel...
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ژورنال
عنوان ژورنال: Advances in Therapy
سال: 2015
ISSN: 0741-238X,1865-8652
DOI: 10.1007/s12325-015-0206-4